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"Yes, enabling HTTP pipelining can dramatically improve networking performance. The downside, and the reason it's not enabled by default, is that it can prevent Web pages from displaying correctly."

"The second change, setting the initial paint delay at zero, may get you some content on the screen faster, but it's worth noting that it will dramatically slow down the time it takes the entire page to display."

"Yes, there are tuning change you can make (even at compile time, see Moox' optimized builds) that will dramatically alter the performance characteristics of Firefox. Feel free to experiment, but remember that most of the defaults are defaults for a reason. If your browser starts misbehaving or web sites look broken, it might be worth going back to default settings."
http://weblogs.mozillazine.org/asa/archives/007164.html